2019. Potential Association of Doxycycline With the Onset of Primary Sclerosing Cholangitis: A Case Series
Authors: Buness JG, Ali AH, Tabibian JH, Buness CW, Cox KL, Lindor KD
Journal: [published online ahead of print, 2019 Aug 30]. Am J Ther. 2019;10.1097/MJT.0000000000001065. doi:10.1097/MJT.0000000000001065
Excerpts:
"Primary sclerosing cholangitis (PSC) is linked to inflammatory bowel diseases (IBD). Evidence suggests an association between the gut microbiome and PSC. However, the putative relationship between exposure to antibiotics and onset of PSC has never been reported. We observed 3 cases in which patients without antecedent liver or bowel issues developed symptoms leading to diagnosis of IBD and subsequently PSC after being exposed to doxycycline. We aimed to identify, through the PSC Partners national patient registry, additional cases of PSC in which there is a temporal relationship between exposure to doxycycline and onset of PSC or PSC-IBD."